Who is Doctor Tsubota?

Selected Publications

  • Tsubota K, Satake Y, Kaido M, Shinozaki N, Shimmura S, Bissen-Miyajima H, Shimazaki J. Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. New England Journal of Medicine. 1999;340:1697-1703.
  • Tsubota K, Kawashima M, Inaba T, Dogru, M, Ogawa Y, Nakamura S, Shinmura K, Higuchi A, Kawakita T. The era of antiaging ophthalmology comes of age: antiaging approach for dry eye treatment. Ophthalmic Res 2010;44(3): 146-154.
  • Nakamura S, Kinoshita, S, Yokoi, N, Ogawa, Y, Shibuya, M, Nakashima, H, Hisamura, R, Imada, T, Imagawa, T, Uehara, M, Shibuya, I, Dogru, M, Ward, S, Tsubota, K. Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. PLoS ONE 2010;5(6): e11119.
  • Imamura Y, Noda S, Hashizume K, Shinoda K, Yamaguchi M, Uchiyama S, Shimizu T, Mizushima Y, Shirasawa T, Tsubota K. Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11282-7. Epub 2006 Jul 14.
  • Norihiro Nagai, Yuichi Oike, Kanako Izumi, Takashi Urano, Yoshiaki Kubota, Kousuke Noda, Yoko Ozawa, Makoto M. Inoue, Kazuo Tsubota, Toshio Suda, and Susumu Ishida.Angiotensin IIType 1 Receptor-Mediated Inflammation Is Required for Choroidal Neovascularization.Arterioscler. Thromb. Vasc. Biol., Aug 2006; doi:10.1161/01.ATV.0000240050.15321.fe
  • Satoru Yoshida, Shigeto Shimmura, Narihito Nagoshi, Keiichi Fukuda, Yumi Matsuzaki, Hideyuki Okano, Kazuo Tsubota Isolation of multipotent neural crest-derived stem cells from the adult mouse cornea.Stem Cells First published online August 3, 2006; doi:doi:10.1634/stemcells.2006-0156
  • Tsubota K, Hirai S, King LS, Agre P, Ishida N. Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren's syndrome. Lancet. 2001;357:688-689.
  • Tsubota K, Fujita H, Tsuzaka K, Takeuchi T. Mikulicz's disease and Sjogren's syndrome.Investigative Ophthalmology & Visual Science. 2000;41:1666-1673.
  • Shimazaki J, Kaido M, Shinozaki N, Shimmura S, Munkhbat B, Hagihara M, Tsuji K, Tsubota K. Evidence of long-term survival of donor-derived cells after limbal allograft transplantation. Investigative Ophthalmology & Visual Science. 1999;40:1664-1668.
  • Tsubota K, Saito I, Ishimaru N, Hayashi Y. Use of topical cyclosporin a in a primary Sjogren's syndrome mouse model. Investigative Ophthalmology & Visual Science. 1998;39:1551-1559.
  • Tsubota K. Corneal epithelial stem-cell transplantation. Lancet. 1997 May 24;349(9064):1556.
  • Shimazaki J, Yang HY, Tsubota K. Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns. Ophthalmology. 1997;104:2068-2076.
  • Tsubota K, Satake Y, Shimazaki J.Treatment of severe dry eye. Lancet. 1996 Jul 13;348(9020):123.
  • Tsubota K, Toda I, Nakamori K.Poor illumination, VDTs, and desiccated eyes. Lancet. 1996 Mar 16;347(9003):768-9.
  • Tsubota K, Satake Y, Ohyama M, Toda I, Takano Y, Ono M, Shinozaki N, Shimazaki J. Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. American Journal of Ophthalmology. 1996;122:38-52.
  • Tsubota K, Toda I, Saito H, Shinozaki N, Shimazaki J. Reconstruction of the Corneal Epithelium by Limbal Allograft Transplantation for Severe Ocular Surface Disorders. Ophthalmology. 1995;102:1486-1496.
  • Tsubota K, Hata S, Okusawa Y, Egami F, Ohtsuki T, Nakamori K. Quantitative videographic analysis of blinking in normal subjects and patients with dry eye. Archives of Ophthalmology. 1996;114:715-720.
  • Tsubota K, Nakamori K.Dry eyes and video display terminals. N Engl J Med. 1993 Feb 25;328(8):584.

Major Japanese papers

  • 坪田一男. 総説 円錐角膜への新しいアプローチ. 日本コンタクトレンズ学会誌 52:2-11, 2010.
  • 坪田一男 羽藤晋. 角膜の障害と角膜の再生医療 特集1感覚器(視覚と聴覚)障害の新しい治療 学術の動向SCJフォーラム7, 8-12, 2010.]
  • 坪田一男. 特集 眼と機能性食品 1. 眼科における機能性食品の重要性, Functional Food 3: 8-13, 2009.
  • 坪田一男. 「アンチエイジング」 総論. Medical Science Digest 32:170-171, 2006.
  • 坪田一男. 超高齢社会における感覚器医学-眼科学はなにをめざしているのか-. 医学のあゆみ 211(10), 医歯薬出版, 2004.