Dry Eye

In 1985, while studying at Harvard, I discovered that I had dry eye syndrome (DES). I knew from my college days in Japan that my eyes soon tired and easily became bloodshot. However, even after becoming an ophthalmologist, I never noticed that I myself had DES. Since that discovery, I have involved myself in the clinical, research, and public awareness facets of this syndrome.

Then came the delightful news. An ophthalmological journal published its spring 2013 ranking of dry eye researchers worldwide and, to my surprise, I was at none other than first place! The evaluation referenced 190 publications I authored or co-authored in peer-reviewed journals over 27 years. With a recent finding that vision deteriorates as a result of DES, I will rededicate my efforts to clarifying the pathology of this disorder and developing remedies to relieve it.

Related activities

  • Department of Ophthalmology Keio University School of Medicine DRY EYE CLINIC

Selected Information

Selected Publications

DECS-J Study Group. A Clinic-based Survey of Clinical Characteristics and Practice Pattern of Dry Eye in Japan. Adv Ther. 2017 Mar;34(3):732-743. doi: 10.1007/s12325-017-0487-x.
Asia Dry Eye Society. New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society. Ocul Surf. 2017 Jan;15(1):65-76. doi: 10.1016/j.jtos.2016.09.003. Epub 2016 Oct 8. Review.
Sleep and mood disorders in women with dry eye disease. Sci Rep. 2016 Oct 12;6:35276. doi: 10.1038/srep35276.
Reducing Short-Wavelength Blue Light in Dry Eye Patients with Unstable Tear Film Improves Performance on Tests of Visual Acuity. PLoS One. 2016 Apr 5;11(4):e0152936. doi: 10.1371/journal.pone.0152936.
Relationship of Corneal Pain Sensitivity With Dry Eye Symptoms in Dry Eye With Short Tear Break-Up Time. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):914-9. doi: 10.1167/iovs.15-18447.
Randomized, Multicenter, Double-Blind Study of the Safety and Efficacy of 1%D-3-Hydroxybutyrate eye drops for Dry Eye Disease. Sci Rep. 2016 Feb 11;6:20855. doi: 10.1038/srep20855.
Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study. Ocul Surf. 2016 Apr;14(2):255-63. doi: 10.1016/j.jtos.2015.12.005.
Abdominal breathing increases tear secretion in healthy women. Ocul Surf. 2015 Jan;13(1):82-7. doi: 10.1016/j.jtos.2014.08.002. Epub 2014 Oct 16.
Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye. PLoS One. 2014 Jun 5;9(6):e99205. doi: 10.1371
Alteration of Tear Mucin 5AC in Office Workers Using Visual Display Terminals: The Osaka Study. JAMA Ophthalmol. 2014 Jun 5. doi: 10.1001
Dry-eye screening by using a functional visual acuity measurement system: the osaka study. Invest Ophthalmol Vis Sci. 2014 May 6;55(5):3275-81. doi: 10.1167
International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I)